At the strategic interface of chemistry and biology, the Wang Group is dedicated to developing and deploying advanced chemical toolkits to dissect and modulate biological complexity. We have established a robust, integrated research paradigm spanning precision organic synthesis, transformative chemical biology, and AI-augmented drug discovery. Our mission is to engineer disruptive therapeutic strategies to address global health challenges, with a focus on oncology, neurodegeneration, and senescence.
Research Areas
Harnessing the power of asymmetric catalysis and photoredox chemistry to streamline the divergent construction of structurally complex and biologically privileged scaffolds. We focus on developing high-efficiency synthetic methodologies that provide rapid access to diverse chemical space for drug discovery.
Exploring click chemistry, proximity labeling, and sophisticated biomacromolecule modulation to elucidate and manipulate the underlying molecular logic of physiological and pathological processes. By developing novel chemical probes, we aim to visualize and control protein functions in their native biological environments.
Integrating Artificial Intelligence with rational molecular design to accelerate the development of next-generation Targeted Protein Degradation (TPD) platforms. Notably, the group pioneers the SenoTAC (Senolytic-Targeted Chimera) strategy, providing a leading international framework for the selective clearance of senescent cells and the treatment of age-related diseases.